IMPACT OF LONG-TERM PROBUCOL ADMINISTRATI ON ON BLOOD LIPOPROTEIN CHOLESTEROL LEVELS AND GLUTATHIONE ACTIVITY IN PATIENTS WITH CORONARY ATHEROSCLEROSIS AND HYPERLIPIDEMIA

Authors
LANKIN VZ REVENKO VM LUPANOV VP TIKHAZE AK LYAKISHEV AA KUKHARCHUK VV
Citation
Vz. Lankin et al., IMPACT OF LONG-TERM PROBUCOL ADMINISTRATI ON ON BLOOD LIPOPROTEIN CHOLESTEROL LEVELS AND GLUTATHIONE ACTIVITY IN PATIENTS WITH CORONARY ATHEROSCLEROSIS AND HYPERLIPIDEMIA, Kardiologia, 33(9), 1993, pp. 41-44
Citations number
26
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Kardiologia → ACNP
ISSN journal
00229040
Volume
33
Issue
9
Year of publication
1993
Pages
41 - 44
Database
ISI
SICI code
0022-9040(1993)33:9<41:IOLPAO>2.0.ZU;2-D
Abstract
The authors present results of 6-month probucol (lipomal) therapy in p atients with coronary heart disease concurrent with Types 2a and 2b hy perlipidemia. There were 22 and 23% increases in total cholesterol and low density lipoprotein cholesterol, respectively, whereas the levels of high density lipoprotein decreased and triglycerides remained unch anged. Having antioxidative properties, probucol enhanced the activity of the antioxidative enzyme glutathione peroxidase on an average twic e, which should be borne in mind in evaluating the efficiency of treat ment.