SPLENIC LYMPHOMA WITH VILLOUS LYMPHOCYTES - REPORT OF FIRST 2 CASES FROM THE MIDDLE-EAST

Authors
ALBAHAR S PANDITA R DHABHAR BN ALBAHAR E
Citation
S. Albahar et al., SPLENIC LYMPHOMA WITH VILLOUS LYMPHOCYTES - REPORT OF FIRST 2 CASES FROM THE MIDDLE-EAST, Acta haematologica, 90(4), 1993, pp. 198-201
Citations number
5
Categorie Soggetti
Hematology
Journal title
Acta haematologica → ACNP
ISSN journal
00015792
Volume
90
Issue
4
Year of publication
1993
Pages
198 - 201
Database
ISI
SICI code
0001-5792(1993)90:4<198:SLWVL->2.0.ZU;2-Y
Abstract
Two cases of splenic lymphoma with villous lymphocytes (SLVL) were dia gnosed on the basis of marked splenomegaly, circulating villous lympho cytes, serum IgM monoclonal paraprotein and bone marrow infiltration. Immunological studies confirmed the B cell phenotype (CD19+, CD20+, CD 22+ and CD5- and CD25-). Ultrastructural studies revealed characterist ic uneven villi with polar predisposition. Interferon-alpha therapy in 1 patient did not result in any clinical or hematological improvement . This is the first report of SLVL from the Middle East.