ADENOCARCINOMA OF THE RENAL PELVIS - A REPORT OF 2 CASES

Two cases of intestinal-type adenocarcinoma of the renal pelvis (ARP) in 48-and 63-year-old females are presented. Both had a previous histo ry of urinary obstructive disease, one secondary to staghorn calculus and the other to postir-radiation stenosis following treatment for car cinoma of the cervix. Immunohistochemical findings revealed marked pos itivity to epithelial membrane antigen and focal positivity to cytoker atins and carcinoembryonic antigen. Chronic irritation of the renal pe lvis plays an important role in the pathogenesis of ARP. In one of our cases of multicentric origin, the synergistic effect of pelvic irradi ation and cyclophosphamide chemotherapy in a patient with a previous s quamous cell carcinoma of the cervix, may be responsible for the patho genesis of the ARP.