Gs. Englund et al., DMSA ADMINISTRATION TO PATIENTS WITH ALLEGED MERCURY-POISONING FROM DENTAL AMALGAMS - A PLACEBO-CONTROLLED STUDY, Journal of dental research, 73(3), 1994, pp. 620-628
The present investigation was performed to determine the effect of 14-
day oral administration of meso-2.3-dimercaptosuccinic acid (DMSA) on
the urinary mercury excretion and the potential reduction of blood and
plasma mercury concentrations, and also to relate these effects to po
ssible decrease of symptoms, allegedly associated with amalgam filling
s. Twenty subjects, relating their symptoms to mercury from amalgam fi
llings, received 20 mg/kg DMSA or placebo for 14 days. Their symptoms
and mood states were recorded during the study and at a check-up 3 mon
ths later. Interpretation was based on intra-individual differences. D
MSA-treatment resulted in an average increase in urinary mercury excre
tion by 65% and a decrease in blood mercury levels of 0.04 mu g/L/day.
At the check-up after 3 months, urinary mercury excretion had returne
d to the pre-treatment level. No treatment effect of DMSA was apparent
on subjective symptoms and mood state. One statistically significant
treatment effect was noted-a decrease in fatigue-inertia in the DMSA-g
roup-but there was no demonstrable correlation with increased urinary
excretion or decreased blood concentration of mercury. Three subjects
showed hypersensitive reactions, probably DMSA-specific, at the end of
the treatment period. This placebo-controlled study provides no scien
tific support for diagnostic or therapeutic administration of DMSA for
symptoms allegedly associated with chronic mercury exposition from de
ntal amalgam fillings.