ADVERSE INTERACTION BETWEEN WARFARIN AND INDOMETHACIN

Authors
CHAN TYK LUI SF CHUNG SY LUK S CRITCHLEY JAJH
Citation
Tyk. Chan et al., ADVERSE INTERACTION BETWEEN WARFARIN AND INDOMETHACIN, Drug safety, 10(3), 1994, pp. 267-269
Citations number
NO
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy","Public, Environmental & Occupation Heath
Journal title
Drug safety → ACNP
ISSN journal
01145916
Volume
10
Issue
3
Year of publication
1994
Pages
267 - 269
Database
ISI
SICI code
0114-5916(1994)10:3<267:AIBWAI>2.0.ZU;2-W
Abstract
A 57-year-old man developed spontaneous skin bruising and haematuria d uring combined therapy with warfarin and indomethacin. Due to the pote ntial effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the anticoagulant action of warfarin and platelet function, patients recei ving both warfarin and NSAIDs should have their prothrombin time monit ored very closely. Also, the risk of gastrointestinal haemorrhage with any NSAIDs must always be remembered.