EFFECT OF PGE IN MULTIPLE EXPERIMENTAL-MODELS .9. IN-VIVO EFFECTS OF PGE ON IMMUNE-RESPONSE OF LEUKOCYTES TO WOUNDS

There have been conflicting results obtained when comparing the in vit ro with in vivo effects of prostaglandin E (PGE) on immune function. T he in vitro studies have demonstrated immune suppression with PGE admi nistration while the in vivo studies demonstrated improved survival wh en utilizing infected models. To attempt to resolve this discrepancy, we evaluated the in vivo effect of PGE on host immune function utilizi ng multiple rat models. PGE was found to have no effect on the ability of leucocytes to infiltrate a sponge matrix wound over a 2-week perio d of study. PGE also failed to alter the percentage of T-lymphocyte su bset populations infiltrating the sponge matrix model. There was noted to be no effect of PGE on the ability of neutrophils to chemiluminesc e, or on metabolic function of lymphocytes. In conclusion, PGE does no t appear to have immunosuppressive properties when studied using certa in in vivo models.