Vi. Fomichev et Vp. Pchelintsev, SOME NEUROHUMORAL SYSTEM IN PATIENTS WITH CORONARY HEART-DISEASE AND IN EMOTIONAL PAIN STRESS - MODES OF THEIR PHARMACOLOGICAL REGULATION, Kardiologia, 33(10), 1993, pp. 15-18
The sympathicoadrenal and kallikrein-kinin systems were studied in 225
patients with various coronary heart diseases before and after therap
y with lipoic acid (150 mg/day), tocopherol (100 mg/day), anaprilin (4
0 mg/day), prodectin (750 mg/day) or their combination. Myocardial and
adrenal catecholamine levels were measured in experiments on animals
exposed to emotional pain stress. Their levels were found to be affect
ed by lipoic acid, tocopherol, obsidan or their combinations in the sa
me doses, taking into account species specificity. Lipoic acid therapy
for patients with coronary heart disease decreased epinephrine excret
ion, enhanced the elimination of vanillylmandelic acid and norepinephr
ine. Tocopherol lowered daily urinary epinephrine levels and increased
the release of vanillylmandelic acid, without changing epinephrine ex
cretion. Emotional pain stress resulted in myocardial epinephrine accu
mulation and adrenal norepinephrine in the animals. Lipoic acid preven
ted this accumulation, whereas tocopherol did not possess this effect.