A GENETIC AND EPIDEMIOLOGIC MODEL OF PRED ISPOSITION TO CORONARY HEART

A genetic and epidemiological sample of 20-59-year-old males, Moscow r esidents (n = 3141), was surveyed. The authors obtained data on the pr evalance of coronary heart disease from epidemiological criteria and g enealogical data on cardiovascular diseases by the ''Familial History' ' questionnaire in the first-degree relatives who were interviewed by using a genetic and mathematical monolocus diallelic model. It was fou nd that out of the 10 possible variants under study a genetic and envi ronmental variant with independent penetrance of 3 genotypes adequatel y describes the prevalence of coronary heart disease in the families a nd in the population. This suggest that both genetic and environmental factors have an influence on the prevalence of coronary heart disease and that there is a possible genetic polymorphism of the disease.