LIPID-PEROXIDATION AS A MECHANISM OF PLAT ELET AGGREGABILITY REGULATION

The paper deals with the role of free radical lipid oxidation in the m echanisms of platelet activation. The findings suggest that lipid pero xidation metabolites (primary and secondary) are able to produce regul atory effects mediated by membrane arrangement on platelet aggregatory properties. At the same time the higher levels of conjugated dienes c an induce platelet aggregation in unstable angina pectoris. This expan ds the current concepts of the mechanisms of abnormal platelet activat ion and allows it to be classified as a particular system.