BIOCHEMICAL-STUDY OF CREATINE-PHOSPHOKINA SE IN THE MYOCARDIUM AND ITS MORPHOLOGICAL-CHANGES IN PATIENTS WITH ACUTE VASCULAR SURGICAL ABNORMALITY

The structure and metabolism of various myocardial portions, including the activity of creatine phosphokinase (CPK), were studied by using t he autopsies of patients who had died in a surgical clinic. The bioche mical studies demonstrated a decrease in CPK activity, which was prono unced in patients with atherosclerotic aneurysm and abdominal aortic r upture. The morphological studies revealed individual cardiomyocytic l esions, segmental legions of papillary muscle. There was reduced activ ity of redox enzymes in the frangentation areas of muscle fibers. Vari ous surgical abnormality of vessels was accompanied by progressive myo cardial hypoxia and drastically decreased activity of CPK and the test ed hydroxyreductases.