MODIFICATIONS OF SOLUTION FOR REPERFUSION OF ISCHEMIC HEART

Authors
KAPELKO VI PISARENKO OI PUKHOVA TM LAKOMKIN VL SOLOMATINA YS STUDNEVA IM
Citation
Vi. Kapelko et al., MODIFICATIONS OF SOLUTION FOR REPERFUSION OF ISCHEMIC HEART, Kardiologia, 33(10), 1993, pp. 71-74
Citations number
19
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Kardiologia → ACNP
ISSN journal
00229040
Volume
33
Issue
10
Year of publication
1993
Pages
71 - 74
Database
ISI
SICI code
0022-9040(1993)33:10<71:MOSFRO>2.0.ZU;2-2
Abstract
Isolated working guinea pig hearts were subjected to 30-min total norm othermic ischemia and 30-mi reperfusion with modified Krebs solution t o which various agents were added. The presence of glutamate in the so lution resulted in better recovery of cardiac pump function and higher myocardial energy phosphate levels. Addition of phrelone, a calmoduli n inhibitor, or adenosine and ribose did not improve pump function. Th e similar functional recovery was observed after addition of taurine i ns tead of glutamate and their combination exerted even higher functio nal recovery while further addition of phosphocreatine was not so effe ctive.