SLE(X) EXPRESSION OF NORMAL CD34 POSITIVE BONE-MARROW HEMATOPOIETIC PROGENITOR CELLS

Authors
KARAKANTZA M GIBSON FM CAVENAGH JD BALL SE GORDON MY GORDONSMITH EC
Citation
M. Karakantza et al., SLE(X) EXPRESSION OF NORMAL CD34 POSITIVE BONE-MARROW HEMATOPOIETIC PROGENITOR CELLS, British Journal of Haematology, 86(4), 1994, pp. 883-886
Citations number
12
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
86
Issue
4
Year of publication
1994
Pages
883 - 886
Database
ISI
SICI code
0007-1048(1994)86:4<883:SEONCP>2.0.ZU;2-N
Abstract
We investigated sialylated Lewis x (sLe(x)) antigen expression on CD34 positive (CD34(+)) haemopoietic progenitors in the bone marrow of eig ht healthy volunteers using monoclonal antibodies. We found that in al l the samples examined, CD34(+) bone marrow progenitors strongly expre ssed the sLe(x) antigen. This contradicts previous publications which reported sLe(x) expression on malignant blast cells but not on normal CD34(+) progenitor cells.