E. Disla et al., IMPROVEMENT IN CD4 LYMPHOCYTE COUNT IN HIV-REITERS SYNDROME AFTER TREATMENT WITH SULFASALAZINE, Journal of rheumatology, 21(4), 1994, pp. 662-664
Objective. To describe an observed improvement in CD4 lymphocytes in p
atients with Reiter's syndrome (RS) and human immunodeficiency virus (
HIV) infection, after treatment with sulfasalazine (SFSZ). Methods. Ca
se series. We analyzed CD4 lymphocyte counts in 4 consecutive patients
with RS and HIV disease before and after treatment with SFSZ. Results
. CD4+ lymphocyte counts increased from a mean of 315 +/- 179 before t
reatment to 542 +/- 231 x 10(6)/1 on followup (p < 0.03), in the absen
ce of antiretroviral therapy. The significance of these observations i
s discussed. Conclusion. Treatment of RS with SFSZ in HIV disease appe
ars to be associated with an improvement in CD4 count.