PARENTAL ORIGINS OF CHROMOSOME-7 LOSS IN CHILDHOOD MONOSOMY-7 SYNDROME

Bone marrow monosomy 7 (Mo 7) is associated with childhood preleukemic myeloproliferative and myelodysplastic syndromes (MPS and MDS). We us ed a series of polymorphic markers to investigate the parental origins of chromsomes lost from the bone marrows of 12 children with MPS/MDS and Mo 7. Eight Mo 7 bone marrows lost a maternal chromosome 7 and fou r cases lost the paternal homologue. Our data and the results of previ ous laboratory and clinical observations in thefamilial and sporadic f orms of childhood Mo 7 suggest that chromosome 7 deletions contribute to leukemogenesis by gene dosage.