DE-NOVO PH-NEGATIVE ACUTE T-LYMPHOBLASTIC LEUKEMIA WITH BCR GENE REARRANGEMENT

We herein report a rare case of Ph chromosome-negative acute T-lymphob lastic leukemia (T-ALL) with a classical BCR rearrangement seen in chr onic myelogenous leukemia (CML). There were no clinical or morphologic features to suggest a previous chronic phase of CML. The importance o f a full analysis of the BCR gene in the case of adult acute lymphobla stic leukemia (ALL), especially in T-ALL, are discussed.