An uncommon cause of sepsis in patients with large burns is occult int
racompartmental infection. A multi-institution review of 1171 burn adm
issions identified 5 patients (0.4%) who developed intracompartmental
sepsis presenting with fever and purulent drainage or fever, erythema,
and swelling on clinical examination. Contributing factors may have i
ncluded high-volume resuscitation, delayed escharotomy, extravasated i
ntraosseous infusion, cannulation-related arterial injury, and splinti
ng or positioning difficulties. A high index of suspicion and an aggre
ssive surgical approach facilitate successful management of this unusu
al problem.