Se. Bellibas et al., LITHIUM AND ANTICHOLINERGIC COMBINATION TO MAINTAIN A STABLE LITHIUM PLASMA-LEVEL, Human psychopharmacology, 9(1), 1994, pp. 33-36
The effect of lithium and propantheline, an anticholinergic agent, com
bination on plasma and red blood cell (RBC) lithium levels was studied
to test if this combination could maintain a stable plasma lithium le
vel for a long-lasting period by delaying gastric emptying, in rabbits
. There was a significant difference in plasma lithium levels between
control and propantheline-administered groups (p < 0.01). The peak lev
el seen in the second hour of lithium administration in the control gr
oup was not observed in the propantheline-administered group and a sta
ble lithium level was maintained. It was suggested that a lithium and
anticholinergic drug combination can be an alternative in eliminating
the peak plasma levels of lithium and preventing the side-effects thou
ght to berelated to this factor.