REGULATION OF GONADOTROPIN RECEPTOR GENE-EXPRESSION

Authors
THEMMEN APN KRAAIJ R GROOTEGOED JA
Citation
Apn. Themmen et al., REGULATION OF GONADOTROPIN RECEPTOR GENE-EXPRESSION, Molecular and cellular endocrinology, 100(1-2), 1994, pp. 15-19
Citations number
46
Categorie Soggetti
Endocrynology & Metabolism","Cytology & Histology
Journal title
Molecular and cellular endocrinology → ACNP
ISSN journal
03037207
Volume
100
Issue
1-2
Year of publication
1994
Pages
15 - 19
Database
ISI
SICI code
0303-7207(1994)100:1-2<15:ROGRG>2.0.ZU;2-X
Abstract
The receptors for the gonadotropins differ from the other G protein-co upled receptors by having a large extracellular hormone-binding domain , encoded by nine or ten exons. Alternative splicing of the large pre- mRNA of approximately 100 kb can result in mRNA species that encode tr uncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the possible roles of alter native splicing in gonadotropin receptor function.