RELATIONSHIP OF ENDOMETRIAL THICKNESS WITH THE MENSTRUAL TIMING OF LEUPROLIDE ACETATE ADMINISTRATION FOR PREOPERATIVE PREPARATION FOR HYSTEROSCOPIC SURGERY

Study Objectives. To assess the relationship of menstrual timing if ad ministration of gonadotropin-releasing hormone (GnRH) agonist on the e ffectiveness of endometrial thinning and unwanted uterine bleeding. De sign. Prospective observational study. Setting. Gynecology department of a community hospital. Patients. One hundred consecutive women in a private practice, without submucous myomas, scheduled for transcervica l endomyometrial resection or ablation. interventions. A GnRH agonist was administered at an unspecified time of the menstrual cycle. Transc ervical hysteroscopic endomyometrial resection or ablation was perform ed I month later. Measurements and Main Results. No significant statis tical differences were seen in either the effectiveness of endometrial thinning or the occurrence or severity of unwanted uterine bleeding. Conclusions. A GnRH agonist as pretreatment for endomyometrial resecti on or ablation can be administered at any time during the menstrual cy cle with similar efficacy Timing of surgery can be at the mutual conve nience of patient and physician.