GENOTOXICITY AND CYTOTOXICITY OF 3-AMINO-1-METHYL-5H-PYRIDO[4,3-B]INDOLE (TRP-P-2)

Authors
SEGAWA T ISHIGA H UENO H NAKAMURO K SAYATO Y
Citation
T. Segawa et al., GENOTOXICITY AND CYTOTOXICITY OF 3-AMINO-1-METHYL-5H-PYRIDO[4,3-B]INDOLE (TRP-P-2), Chemosphere, 28(5), 1994, pp. 853-861
Citations number
23
Categorie Soggetti
Environmental Sciences
Journal title
Chemosphere → ACNP
ISSN journal
00456535
Volume
28
Issue
5
Year of publication
1994
Pages
853 - 861
Database
ISI
SICI code
0045-6535(1994)28:5<853:GACO3>2.0.ZU;2-F
Abstract
Trp-P-2 caused cytotoxicity in the form of leakage of DNase and death of cells in rat hepatocytes. The enhancement of cytotoxic responses de pends on the activity of cytochrome P-450 in rat hepatocytes. The cyto toxicity contributed to the genotoxicity as indirect DNA lesion caused by the release of DNase.