STEMODIN SYNTHESIS .2. HIGHLY DIASTEREOSELECTIVE FORMAL TOTAL SYNTHESIS OF (PLUS-OR-MINUS)-STEMODIN VIA PD2-PROMOTED CYCLOALKENYLATION REACTION()

Authors
TOYOTA M SEISHI T FUKUMOTO K
Citation
M. Toyota et al., STEMODIN SYNTHESIS .2. HIGHLY DIASTEREOSELECTIVE FORMAL TOTAL SYNTHESIS OF (PLUS-OR-MINUS)-STEMODIN VIA PD2-PROMOTED CYCLOALKENYLATION REACTION(), Tetrahedron, 50(12), 1994, pp. 3673-3686
Citations number
48
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
12
Year of publication
1994
Pages
3673 - 3686
Database
ISI
SICI code
0040-4020(1994)50:12<3673:SS.HDF>2.0.ZU;2-7
Abstract
Diastereoface-selective Pd2+-promoted cycloalkenylation reaction (22-- >24) has been employed as the key step for a conceptually new and high ly diastereocontrolled formal total synthesis of (+/-)-stemodin (1). I nterestingly, the synthetic intermediates (12) and its stereoisomer (2 9) exhibited strong cytotoxicity.