CYCLOSPORINE-A AGAINST METHOTREXATE AND A ZATHIOPRINE TREATMENT OF RHEUMATOID-ARTHRITIS - COMPARISON OF THE RESULTS IN A PILOT-STUDY

Authors
USOVA SB SIGIDIN YA
Citation
Sb. Usova et Ya. Sigidin, CYCLOSPORINE-A AGAINST METHOTREXATE AND A ZATHIOPRINE TREATMENT OF RHEUMATOID-ARTHRITIS - COMPARISON OF THE RESULTS IN A PILOT-STUDY, Terapevticeskij arhiv, 65(5), 1993, pp. 65-69
Citations number
8
Categorie Soggetti
Medicine, General & Internal
Journal title
Terapevticeskij arhiv → ACNP
ISSN journal
00403660
Volume
65
Issue
5
Year of publication
1993
Pages
65 - 69
Database
ISI
SICI code
0040-3660(1993)65:5<65:CAMAAZ>2.0.ZU;2-A
Abstract
In a randomized trial 43 patients with RA systemic manifestations rece ived for 6 months immunodepressants: azathioprin, methotrexate and cyc losporin A (12,15 and 16 patients, respectively). Ten more patients re sistant to immunodepressants were given cyclosporin A. The drugs were found to produce a positive effect on clinical symptoms and laboratory indices of the disease. Cyclosporin A is thought a basic immunodepres sant without serious hematological or infectious complications. Occasi onally it can be useful in failure of other immunodepressants administ ered to RA patients.