Vg. Kukes et al., THEOPHYLLINE PHARMACOKINETICS IN CHRONIC NONSPECIFIC INTESTINAL-DISEASES UNDER DIFFERENT INTRODUCTION TO PATIENTS, Terapevticeskij arhiv, 65(2), 1993, pp. 52-54
Theophylline pharmacokinetics was investigated upon introduction of eu
phylline (0.15 g) at four levels of gastrointestinal tract: orally (20
patients), into the jejunum (15 patients) at enterogastroduodenoscopy
, in the ileocecal area (8 patients) at colonoscopy and rectally (9 pa
tients). Absorption speed depended on the variant of the gastrointesti
nal introduction rather than on the variant of chronic nonspecific int
estinal disease, and appeared maximal in the drug introduction into th
e jejunum. Concentration and area under curve became maximal in minor
participation of the liver in primary capture and biotransformation of
theophylline. Reduced theophylline doses are recomeended in lower hep
atic metabolism of the drug, in hepatic hypofunction, in rectal route
of administration.