THEOPHYLLINE PHARMACOKINETICS IN CHRONIC NONSPECIFIC INTESTINAL-DISEASES UNDER DIFFERENT INTRODUCTION TO PATIENTS

Theophylline pharmacokinetics was investigated upon introduction of eu phylline (0.15 g) at four levels of gastrointestinal tract: orally (20 patients), into the jejunum (15 patients) at enterogastroduodenoscopy , in the ileocecal area (8 patients) at colonoscopy and rectally (9 pa tients). Absorption speed depended on the variant of the gastrointesti nal introduction rather than on the variant of chronic nonspecific int estinal disease, and appeared maximal in the drug introduction into th e jejunum. Concentration and area under curve became maximal in minor participation of the liver in primary capture and biotransformation of theophylline. Reduced theophylline doses are recomeended in lower hep atic metabolism of the drug, in hepatic hypofunction, in rectal route of administration.