NEUROHUMORAL AND HEMODYNAMIC-EFFECTS OF A LDIZEM IN PATIENTS WITH STABLE AND UNSTABLE ANGINA-PECTORIS

Authors
MALAYA LT ABIDOV AA KNYAZKOVA II
Citation
Lt. Malaya et al., NEUROHUMORAL AND HEMODYNAMIC-EFFECTS OF A LDIZEM IN PATIENTS WITH STABLE AND UNSTABLE ANGINA-PECTORIS, Terapevticeskij arhiv, 65(2), 1993, pp. 55-58
Citations number
15
Categorie Soggetti
Medicine, General & Internal
Journal title
Terapevticeskij arhiv → ACNP
ISSN journal
00403660
Volume
65
Issue
2
Year of publication
1993
Pages
55 - 58
Database
ISI
SICI code
0040-3660(1993)65:2<55:NAHOAL>2.0.ZU;2-G
Abstract
A study is presented of hemodynamic effects and reactions of prostacyc lin - thromboxane system in patients with stable (63 pts) and unstable angina pectoris (57 pts) who took aldizem 240 mg daily during 3 week. It was found that the aldizem improved clinical and hemodynamic indic ies and increased plasma concentration of 6-keto-PGF1alpha and FPE2, b ut reduced TxB2 and PGF2alpha. Also these changes depended on time of therapy: long-term therapy resulted in improvement of the prostacyclin -thromboxane balance.