NEOTON IN THE TREATMENT OF MYOCARDIAL-INF ARCTION AND UNSTABLE ANGINA-PECTORIS

A total of 485 patients with complicated myocardial infarction (MI) in the presence of concurrent abnormality and 104 patients with unstable angina (UA) were followed up. Intravenous infusion of neoton (phospho creatine) in a dose of 70 g at day 1 and 36 g at days 2 and 3 of the o nset was made in 96 patients with MI, 28 patients with UA took neoton in a daily dose of 30 g during 3 days. Control patients had convention al therapy. In UA, poor outcomes (death, MI, no effects, referral of p atients for bypass surgery) were seen in 4 (14%) patients on the drug and in 18 (28 %) in the controls (p > 0.05). I MI, more rapid disappea rance of events (heart failure and tachyarrhythmias) was observed in t he major group, the mortality being 13.9%, the incidence of cardiac ru ptures 6.4 versus 33.6 and 12.6% respectively, in the control. It is c oncluded that large-dose neoton exerts positive action on the cause an d outcome of UA and complicated MI.