A method for partitioning topologically chiral knots into mutually het
erochiral classes has been developed, based on the principle that for
such knots there exist no diagrams whose vertex-bicolored graphs are c
omposed of equivalent black and white subgraphs. The method, which int
roduces the concept of writhe profiles, is successfully applied to alt
ernating as well as non-alternating prime and composite knots, and wor
ks in cases where the Jones and Kauffman polynomials fail to recognize
the knot's chirality. It is shown that writhe profiles are sensitive
indicators of diagram similarity.