OVARIAL STIMULATION WITH VARIOUS FSH-LH C ONCENTRATIONS IN AN IN-VITRO FERTILIZATION PROGRAM

Various stimulation regimes have been tried to induce multiple follicu lar development for in-vitro fertilisation and embryo transfer. Human menopausal gonadotrophins have been widely used to induce follicular g rowth. To evaluate the role of the FSH: LH-ratio and the importance of LH concentrations, the results of a randomised assessor-blind group c omparative efficacy and safety study are described. The effects of pre parations, comprising FSH: LH-ratio of 3 : 1 and FSH: LH-ratio of 1 : 1 respectively, in stimulation of the ovaries for in-vitro fertilisati on in infertile women are compared. Patients under 38 years of age wit h regular menstrual cycle (27 +/- 3 days and 32 +/- 3 days) are includ ed. Sperm parameters have to be in normal range, according to WHO crit eria, Follicular and luteal hormone parameters, ultrasound measurement s, oocyte quality, fertilisation, cleavage and pregnancy rates are rep orted. The outcome of in-vitro fertilisation after the administration of preparations containing different ratios of FSH: LH leads to compar able results. However, the rate of ovarian hyperstimulation syndrome a nd the abortion rate after embryo transfer seems to be lower in patien ts stimulated with FSH dominant gonadotrophins.