K. Diedrich et al., OVARIAL STIMULATION WITH VARIOUS FSH-LH C ONCENTRATIONS IN AN IN-VITRO FERTILIZATION PROGRAM, Geburtshilfe und Frauenheilkunde, 54(3), 1994, pp. 167-170
Various stimulation regimes have been tried to induce multiple follicu
lar development for in-vitro fertilisation and embryo transfer. Human
menopausal gonadotrophins have been widely used to induce follicular g
rowth. To evaluate the role of the FSH: LH-ratio and the importance of
LH concentrations, the results of a randomised assessor-blind group c
omparative efficacy and safety study are described. The effects of pre
parations, comprising FSH: LH-ratio of 3 : 1 and FSH: LH-ratio of 1 :
1 respectively, in stimulation of the ovaries for in-vitro fertilisati
on in infertile women are compared. Patients under 38 years of age wit
h regular menstrual cycle (27 +/- 3 days and 32 +/- 3 days) are includ
ed. Sperm parameters have to be in normal range, according to WHO crit
eria, Follicular and luteal hormone parameters, ultrasound measurement
s, oocyte quality, fertilisation, cleavage and pregnancy rates are rep
orted. The outcome of in-vitro fertilisation after the administration
of preparations containing different ratios of FSH: LH leads to compar
able results. However, the rate of ovarian hyperstimulation syndrome a
nd the abortion rate after embryo transfer seems to be lower in patien
ts stimulated with FSH dominant gonadotrophins.