A CONVERGENT SYNTHESIS OF AN LTD(4) ANTAGONIST, RG12525

Authors
SLEDESKI AW OBRIEN MK TRUESDALE LK
Citation
Aw. Sledeski et al., A CONVERGENT SYNTHESIS OF AN LTD(4) ANTAGONIST, RG12525, Tetrahedron letters, 38(7), 1997, pp. 1129-1132
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
7
Year of publication
1997
Pages
1129 - 1132
Database
ISI
SICI code
0040-4039(1997)38:7<1129:ACSOAL>2.0.ZU;2-I
Abstract
An efficient, convergent synthesis of an LTD(4) antagonist, RG12525 (1 ) has been achieved through the alkylation of the (2-quinolinylmethoxy )phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synth ons 4a and 4b, as well as novel preparation of 2 is described. (C) 199 7, Elsevier Science Ltd.