AN EFFICIENT SYNTHESIS OF A GAL-BETA-1-3GALNAC-SERINE DERIVATIVE USING BETA-GALACTOSIDASE

Authors
SUZUKI K FUJIMOTO H ITO Y SASAKI T AJISAKA K
Citation
K. Suzuki et al., AN EFFICIENT SYNTHESIS OF A GAL-BETA-1-3GALNAC-SERINE DERIVATIVE USING BETA-GALACTOSIDASE, Tetrahedron letters, 38(7), 1997, pp. 1211-1214
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
7
Year of publication
1997
Pages
1211 - 1214
Database
ISI
SICI code
0040-4039(1997)38:7<1211:AESOAG>2.0.ZU;2-0
Abstract
An efficient route for the synthesis of Gal beta 1-3GalNAc alpha 1-O-S erine derivative was developed using a novel beta 1-3 galactosidase ob tained from Bacillus circulans. By a transglycosylation reaction with pNP-beta-Gal 2 as a donor and GalNAc alpha-O-Z-Ser-OAll 4 as an accept or, Gal beta 1-3GalNAc alpha-1-O-Z-Ser-OAll 5 was synthesized in 68% y ield. (C) 1997, Elsevier Science Ltd.