KINETICS OF SOLVOLYSIS OF 2-CHLOROQUINOXALINE

Pseudo-first-order rate constants and activation parameters have been measured for the solvolysis of 2-chloroquinoxaline in various aquo-org anic mixtures using methanol, ethanol, and isopropanol as the organic solvent. Excellent linear correlations are found between lnk and the m ol fraction of cosolvent and ln[H2O]. The medium effect on the rates o f solvolysis is assessed by Grunwald - Winstein's mY correlationship. The estimated values of m (0.55-0.72) and the entropy of activation (1 48-212 J deg-1 mol-1) for the reactions are well in the range for a bi molecular aromatic substitution reactions. (C) 1994 John Wiley & Sons, Inc.