Objective. To determine if high-dosage, extensive photoirradiation of
the prostate could be used safely in men with large prostate glands an
d obstruction, coupled with acceptable clinical results. Methods. Trea
tment of 25 men consecutively with eight quadrant photoirradiation of
the prostate. Treatment of the next 25 men with high-dosage energy up
to 109,000 joules. Simultaneous transrectal needle biopsy of the prost
ate performed on all 50 men after treatment. Patients evaluated with f
our- to sixteen-month follow-up. Results. Success rate of 86 percent o
n all patients with mean American Urological Association (AUA) symptom
score decreasing by nineteen points and mean peak uroflow rate increa
sing by 7.9 cc. Needle biopsy after high-dosage laser therapy shows no
laser effect on the peripheral zone. Conclusions. High-dosage laser e
nergy can be used safely, and allows us to treat large prostates with
excellent clinical results and minimal complications.