SELF-EMULSIFYING DRUG-DELIVERY SYSTEMS (SEDDS) WITH POLYGLYCOLYZED GLYCERIDES FOR IMPROVING IN-VITRO DISSOLUTION AND ORAL ABSORPTION OF LIPOPHILIC DRUGS

The ability of polyglycolyzed glycerides (PGG) with varying fatty acid and polyethylene glycol (PEG) chain lengths to produce the self-emuls ification of oil in water has been investigated. The quality of the re sulting emulsions depends on the oil and emulsifier pair selected. The se self-emulsifying drug delivery systems (SEDDS) were prepared using various concentrations of PGG as emulsifiers. Two oils, a medium-chain triglyceride (Neobee M5) and Peanut Oil, were chosen as the vehicle f or the drug. A lipophilic drug with excellent oil solubility was selec ted for this study. The droplet size distribution, the release rate of the drug and the oil/water partition coefficient (PCo/w) of the drug in these systems were evaluated for the SEDDS obtained. The results in dicate that PGG are effective emulsifiers for SEDDS. Droplet particle size in combination with droplet polarity in the emulsion are prerequi sites for efficient SEDDS. The PCo/w of the drug from these SEDDS is h elpful in evaluating these properties. A phase diagram was used to obt ain the optimum concentrations of drug, oil and emulsifying agent. The results obtained with PGG were compared with previously reported SEDD S for the efficiency of drug release (Bachynsky et al., (1989) AAPS An nual Meeting). In vitro dissolution and in vivo absorption of a lipoph ilic drug from SEDDS are compared with those properties of other dosag e forms.