IN-VIVO EVALUATION OF INDOMETHACIN CYCLODEXTRIN COMPLEXES - GASTROINTESTINAL TOLERANCE AND DERMAL ANTIINFLAMMATORY ACTIVITY/

Inclusion complexes of indomethacin in beta-cyclodextrin and hydroxypr opyl-beta-cyclodextrin were prepared and evaluated in vivo. With respe ct to the gastrointestinal tolerance assessed in the rat, it appears t hat the inclusion of indomethacin in these cyclodextrins results in a decrease in its irritation power, confirming that this undesirable eff ect has at least a local origin. With respect to the dermal anti-infla mmatory activity assessed on healthy volunteers by the methyl nicotina te test, the results seem to demonstrate that inclusions in either of the cyclodextrins investigated have a higher activity than free indome thacin.