PHOSPHOLIPID-COMPOSITION OF R-DNA HEPATITIS-B SURFACE-ANTIGENS

Authors
VANDERMEEREN P VANCRIEKINGE W VANDERDEELEN J BAERT L
Citation
P. Vandermeeren et al., PHOSPHOLIPID-COMPOSITION OF R-DNA HEPATITIS-B SURFACE-ANTIGENS, International journal of pharmaceutics, 106(1), 1994, pp. 89-92
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
106
Issue
1
Year of publication
1994
Pages
89 - 92
Database
ISI
SICI code
0378-5173(1994)106:1<89:PORHS>2.0.ZU;2-C
Abstract
The composition of the lipid matrix of the antigenic protein of r-DNA hepatitis B surface antigen (HBsAg) particles was investigated. High-p erformance liquid chromatography (HPLC) revealed that the lipid fracti on contained mainly neutral lipids, as well as phosphatidylcholine, ph osphatidylinositol and phosphatidylethanolamine. In addition, it was s hown that these lipids contained primarily C16 and C18 saturated and m ono-unsaturated fatty acids. Comparing these results to literature dat a concerning blood plasma HBsAg particles, significant differences wer e observed.