SEROTYPE G6 HUMAN ROTAVIRUS SHARING A CONSERVED GENETIC CONSTELLATIONWITH NATURAL REASSORTANTS BETWEEN MEMBERS OF THE BOVINE AND AU-1 GENOGROUPS - BRIEF REPORT

Serotype G6 human rotavirus PA151 was examined by RNA-RNA hybridizatio n in comparison with another G6 strain PA169 and two naturally-occurri ng G3 reassortants PCP5 and MZ58. PA151 possessed three gene segments that formed hybrids with AU-1 and seven gene segments that formed hybr ids with bovine rotavirus NCDV. PA151 also possessed eight, 10 and 10 gene segments that formed hybrids with genomic RNAs from PA169, PCP5, and MZ58, respectively. Thus, PA151 was an intergenogroup reassortant formed in nature between members of the bovine and AU-1 genogroups and it shared a genome constellation with PA169, PCP5, and MZ58. These re sults suggest that naturally-occurring intergenogroup reassortants pos sessing such a genome constellation were perpetuated in human populati ons.