NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF THE GLYCOPROTEIN GENE OF RABIES VIRUS-VACCINE STRAIN VNUKOVO-32 - BRIEF REPORT

The glycoprotein gene of the rabies virus vaccine strain Vnukovo-32 wa s sequenced and the deduced protein sequence was analyzed and compared with that of various laboratory and street strains. The amino acid se quence homologies of strain Vnukovo-32 were compared with fixed strain s ERA, SAD B19, PV, HEP-Flury, CVS and two street strains, canine and CXX89-1, were 98.9% (6 replacements), 98.3% (9), 96.2% (20), 91.4% (45 ), 87.0% (68), 93.5% (34) and 91.4% (45), respectively. Sequence align ments of the proteins revealed that the most conserved region is the e ctodomain, whereas the transmembrane and cytoplasmic domains showed si gnificant divergence.