EFFECT OF EARLY MENOPAUSE DUE TO OVARIECTOMY ON BONE LOSS

Citation
Jm. Pouilles et al., EFFECT OF EARLY MENOPAUSE DUE TO OVARIECTOMY ON BONE LOSS, La Presse medicale, 23(14), 1994, pp. 653-656
Citations number
17
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
07554982
Volume
23
Issue
14
Year of publication
1994
Pages
653 - 656
Database
ISI
SICI code
0755-4982(1994)23:14<653:EOEMDT>2.0.ZU;2-C
Abstract
Objectives: Early menopause is a well-known risk factor for osteoporos is. It could be an aggravating factor when induced ovariectomy. This s tudy was conducted to compare vertebral bone density and biochemical m arkers of bone remodelling in patients with spontaneous and induced ea rly and ''normal'' menopause. Methods: The main biochemical markers of bone remodelling (serum calcium, albumin, alkaline phosphatase, osteo calcin and urinary calcium/creatinine) together with bone density (L2 - IA) were measured in 55 women (age 46-77 at inclusion) with spontane ous (n = 16) or surgically induced (n = 39) early menopause (before ag e 40) and in 227 women (age at inclusion 47-67 years) with normal meno pause (after 40 years) either spontaneous (n = 136) or surgically indu ced (n = 91). Results: At equivalent ages, vertebral bone density was 7 to 12% lower (p < 0.05) in women with early menopause than in women menopaused after 40. However, the serum levels of alkaline phosphatase and osteocalcin as well as the Nordin index were similar in the two g roups. After adjusting for the duration of menopause, women with early menopause did not have a higher bone density than their ''normal'' me nopause conterparts despite their younger age (9 years younger). No di fferences were observed between spontaneous and surgically induced men opause. Conclusion: These results suggest that bone loss is more rapid or more long lasting after precocious menopause. Surgically induced m enopause does not appear to aggravate bone loss independently of age. Effective prevention of this hormone dependent bone loss is required.