PURPOSE: To assess the need for follow-up esophagography with barium-c
ontaining contrast medium after examination with a water-soluble contr
ast medium in the detection of esophageal perforation. MATERIALS AND M
ETHODS: Sisty-seven patients suspected of having esophageal perforatio
n were examined prospectively with use of an aqueous contrast medium d
uring a 1-year period. The examinations were performed with a digital
fluoroscopy unit Eighteen patients without proved extravasation at eso
phagography performed with aqueous contrast medium and without other c
ontraindications underwent esophagography with barium-containing contr
ast medium. RESULTS: In four of 18 patients (22%) with unremarkable fi
ndings at esophagography performed with a water-soluble contrast mediu
m, a perforation was detected subsequently with use of a barium-contai
ning contrast medium. No complications related to barium extravasation
occurred. CONCLUSION: Patients suspected of having esophageal perfora
tion and who have unremarkable findings at esophagography with water-s
oluble contrast media need to undergo follow-up esophagography with a
barium-containing contrast medium. The use of a digital fluoroscopy un
it does not obviate the follow-up examination.