The H reflex of flexor carpi radialis and radial-induced reciprocal in
hibition were recorded in normal subjects during conditioning stimulat
ion of the contralateral median or radial nerves. It was found that st
imulation of the contralateral median nerve enhanced the degree of rec
iprocal inhibition exerted by the radial nerve on the median nerve, wh
ile contralateral radial nerve stimulation reduced the reciprocal inhi
bition exerted by the extensor on the flexor. In two subjects in which
a pure extensor H reflex was recorded specular features were observed
following contralateral median and radial stimulation. These findings
are considered to be the electrophysiological manifestation of contra
lateral modulation of reciprocal inhibition, which is likely to act at
the level of the IA interneurone.