ANTIFUNGAL PROPERTIES OF LACTOFERRICIN-B, A PEPTIDE DERIVED FROM THE N-TERMINAL REGION OF BOVINE LACTOFERRIN

Authors
BELLAMY W YAMAUCHI K WAKABAYASHI H TAKASE M TAKAKURA N SHIMAMURA S TOMITA M
Citation
W. Bellamy et al., ANTIFUNGAL PROPERTIES OF LACTOFERRICIN-B, A PEPTIDE DERIVED FROM THE N-TERMINAL REGION OF BOVINE LACTOFERRIN, Letters in applied microbiology, 18(4), 1994, pp. 230-233
Citations number
10
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Letters in applied microbiology → ACNP
ISSN journal
02668254
Volume
18
Issue
4
Year of publication
1994
Pages
230 - 233
Database
ISI
SICI code
0266-8254(1994)18:4<230:APOLAP>2.0.ZU;2-S
Abstract
A number of yeasts and filamentous fungi, including agents of skin dis ease (dermatophytes), were tested and found to be susceptible to inhib ition by lactoferricin B. Effective concentrations varied within the r ange of 3 to 60 mu g ml(-1), depending on the strain and culture mediu m used. Lactoferricin B inhibited fungal uptake of H-3-glucose with ef fectiveness similar to polymyxin B, suggesting that it may target the cell membrane. It caused a profound change in ultrastructural features of the dermatophyte Trichophyton mentagrophytes.