2-MONOSUBSTITUTED-1,3-OXAZOLIDINES AS IMPROVED PROTECTIVE GROUPS OF N-BOC-PHENYLISOSERINE IN DOCETAXEL PREPARATION

Authors
DIDIER E FOUQUE E TAILLEPIED I COMMERCON A
Citation
E. Didier et al., 2-MONOSUBSTITUTED-1,3-OXAZOLIDINES AS IMPROVED PROTECTIVE GROUPS OF N-BOC-PHENYLISOSERINE IN DOCETAXEL PREPARATION, Tetrahedron letters, 35(15), 1994, pp. 2349-2352
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
15
Year of publication
1994
Pages
2349 - 2352
Database
ISI
SICI code
0040-4039(1994)35:15<2349:2AIPGO>2.0.ZU;2-3
Abstract
A new route for semisynthetic docetaxel, 1, is described using osubsti tuted-4-phenyl-1,3-oxazolidine-5-carboxylic acids in esterification of 7,10-O-diTroc-10-desacetylbaccatin III (4). Subsequent deprotection o f esters 10(+10') afforded title compound 1 without removal of the Boc group.