ONLINE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDE-PEPTIDE HYBRIDS USINGSILICA SUPPORTS

Authors
TRUFFERT JC LORTHIOIR O ASSELINE U THUONG NT BRACK A
Citation
Jc. Truffert et al., ONLINE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDE-PEPTIDE HYBRIDS USINGSILICA SUPPORTS, Tetrahedron letters, 35(15), 1994, pp. 2353-2356
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
15
Year of publication
1994
Pages
2353 - 2356
Database
ISI
SICI code
0040-4039(1994)35:15<2353:OSSOOH>2.0.ZU;2-A
Abstract
A procedure for the preparation of oligonucleotide-peptide hybrid mole cules by means of automated synthesis is described. The conjugates hav e been assembled on silica supports including CPG (Controlled Pore Gla ss) and Fractosil supports. The novel N-epsilon-lysine protecting grou p, 1-(3,4-dimethyl-2,6-dioxocyclohex-1-ylidene) ethyl (Dde) was used.