SPIROACETAL SYNTHESIS FROM A KEY LACTONE INTERMEDIATE LEADING TO NOVEL C24 AND C25-SUBSTITUTED MILBEMYCINS

Authors
BAKER GH HUSSAIN N MACAULAY GS MORGAN DO DORGAN RJJ
Citation
Gh. Baker et al., SPIROACETAL SYNTHESIS FROM A KEY LACTONE INTERMEDIATE LEADING TO NOVEL C24 AND C25-SUBSTITUTED MILBEMYCINS, Tetrahedron letters, 35(15), 1994, pp. 2381-2384
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
15
Year of publication
1994
Pages
2381 - 2384
Database
ISI
SICI code
0040-4039(1994)35:15<2381:SSFAKL>2.0.ZU;2-9
Abstract
The lactone intermediates (3), (4) and (5) are converted via lithium a cetylide chemistry to a range of novel C24 and C25-substituted milbemy cins. The methodology has been extended to afford milbemycins containi ng 6,5-spiroacetal units.