UTILIZATION OF L-SERINE IN AN OXIME OLEFIN CYCLOADDITION ROUTE TO A FUNCTIONALIZED ASYMMETRIC PYRROLIDINE, A SELECTIVE ALPHA-GLUCOSIDASE INHIBITOR

Authors
HASSNER A FALB E NUDELMAN A ALBECK A GOTTLEIB HE
Citation
A. Hassner et al., UTILIZATION OF L-SERINE IN AN OXIME OLEFIN CYCLOADDITION ROUTE TO A FUNCTIONALIZED ASYMMETRIC PYRROLIDINE, A SELECTIVE ALPHA-GLUCOSIDASE INHIBITOR, Tetrahedron letters, 35(15), 1994, pp. 2397-2400
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
15
Year of publication
1994
Pages
2397 - 2400
Database
ISI
SICI code
0040-4039(1994)35:15<2397:UOLIAO>2.0.ZU;2-I
Abstract
A new route for asymmetric aza-sugar analogs starting with L-serine an d utilizing an intramolecular oxime olefin cycloaddition has been succ essfully developed. A member of this family of branched chain sugar am ino di(hydroxymethyl) pyrrolidines (1 and 2) exhibits selective inhibi tion of alpha-glucosidase, while no inhibition of beta-glucosidase was detected.