Short-term maximal and long-term submaximal regimens of physical exerc
ise hade been assessed for effect on serum lipoproteins in healthy sub
jects, in preclinical coronary heart disease (CHD) sufferers and in ma
nifest CHD patients having food fat-induced lipemia. Fat loading cause
d hypertriglyceridemia in all the examinees. In healthy subjects it wa
s associated with a rise in apo AI, while in CHD patients with relevan
t fall. Maximal exercise in preexisting alimentary hyperlipidemia prov
oked elevation of total cholesterol, triglycerides, LDL cholesterol, b
eing atherogenic. Apo AI grew with a decrease in apoB/apoAI ratio in h
ealthy subjects, in coronary patients apolipoprotein changes were of a
therogenic origin. Prolonged submaximal exercise at the height of food
lipemia resulted in lowering of total cholesterol, triglycerides and
LDL cholesterol along with elevation of HDL cholesterol and apoAI both
in healthy and coronary subjects evidencing antiatherogenicity. It is
noted that the response of lipids and apolipoproteins to fat and phys
ical exercise loads was similar in subclinical and manifest CHD patien
ts.