ANTIAGGREGATION AGENTS EFFECT ON THE COUR SE OF DIABETIC MICROANGIOPATHIES

As shown by conjunctival biomicroscopy, 6-month administration of ticl id and gliclazide induced a statistically significant increase in the frequency of less severe microcirculatory disturbances compared to con ventional hypoglycemic therapy. The drugs also restricted plasmatic im pregnation and cell proliferation in skin biopsy microvascular wall. F ollowing 2-year antiaggregation treatment (gliclazide, trental, dipiri domol) 48,9 % of diabetes mellitus patients achieved regression of mor phological manifestations of diabetic microangiopathy 16,2 % stabiliza tion against 34.9 % of progressive disease cases. Conventional sugar-r educing therapy fails to stop diabetic microangiopathy progression in 73.4-93,3 % of the diabetics.