ANTIGENS HLA CLASS-I AND CLASS-II AND DIF FUSE TOXIC GOITER

Authors
KALININ AP KAMYNINA TS ZARETSKAYA YM ABRAMOV VY KLIMOVA EG KARACHINTSEV VI
Citation
Ap. Kalinin et al., ANTIGENS HLA CLASS-I AND CLASS-II AND DIF FUSE TOXIC GOITER, Terapevticeskij arhiv, 65(3), 1993, pp. 81-85
Citations number
19
Categorie Soggetti
Medicine, General & Internal
Journal title
Terapevticeskij arhiv → ACNP
ISSN journal
00403660
Volume
65
Issue
3
Year of publication
1993
Pages
81 - 85
Database
ISI
SICI code
0040-3660(1993)65:3<81:AHCACA>2.0.ZU;2-4
Abstract
The incidence rate of HLA class I and II antigens has been studied in 168 and 82 patients with diffuse toxic goiter, respectively. Positive association is found for HLA antigens A2, A3, A28, B8, B15, B17, Cw4, DR5; negative one with antigens A24, Bw4, Bw6, Cw1, Cw2, Cw3, Cw5, DR9 . Prevalence of antigens B15, B17, Cw4, DR5 is associated with thyroto xicosis severity, A2 with recurrent toxic goiter. Antigen B8 plays the role of an immunogenetic marker of endocrine ophthalmopathy.