ACUTE PHARMACOLOGICAL BLOCK OF RENIN-ANGI OTENSIN SYSTEM AND RECOVERYOF INTRARENAL HEMODYNAMICS IN CHRONICS WITH GLOMERULONEPHRITIS

A test with capoten, inhibitor of angiotensin-converting enzyme, was e mployed to assess intrarenal hemodynamics (renal functional reserve-RF R) in 17 patients with morphologically confirmend chronic glomerulonep hritis (CGN) in intact renal function without hypertension. Capoten in duced three types of changes: RFR increased (9 cases, 7 patients recov ered RFR), RFR without changes (5 cases), RFR decreased (3 cases, 2 pa tients lost RFR). It is stated that indications to inhibitors of angio tensin-II-converting enzyme in CGN should be based on the initial intr arenal hemodynamics and its changes in response to acute capoten test. Capoten is to be administered in initially reduced or absent RFR and is not to be used in normal RFR without hypertension and functioning k idneys. RFR recovery in the acute capoten test allows long-term treatm ent with inhibitors of angiotensin-converting enzyme.