GLOMERULAR-PERMEABILITY FOR SERUM-PROTEIN S IN CHRONIC GLOMERULOPATHYVARYING IN MORPHOLOGY

Membranous glomerulonephritis (MGN), mesangiocapillary (MCGN), membran oproliferative glomerulonephritis (MPGN) and focal segmental sclerosis or hyalinosis (FSSH) were studied for glomerular filter permeability to serum albumins, IgA and IgG. In MGN the permeability for large-mole cular globulins is not dependent on that for albumin, permeabilities f or the globulins appeared correlated. In MPGN permeability for IgG dep ends on albumins permeability, correlations between that for IgA and I gG are similar to relevant findings in MGN. In MCGN glomerular permeab ility for IgA depends on that for albumins, and IgG depends on IgA per meability. In FSSH better albumin permeability implies increased perme ability for both globulins, while enhanced permeability for IgA entail s the same trend for albumins and IgG. Variable permeability of the gl omerular filter for serum proteins in different morphological forms of chronic glomerulopathy may result from dissimilar defects in diverse layers of the filter and in interaction of basal membrane structures w ith cells responsible for glomerular impermeability for serum proteins .