THEORETICAL APPROACHES TO THE USE OF CYTO STATICS AND CORTICOSTEROIDSIN GLOMERULONEPHRITIS

Cyclophosphamide (CP) and methylprednisolone, (MP) were tried on rats with experimental nephrotoxic serum nephritis and mice with experiment al acute serum nephritis. Pathological processes were analyzed simulta neously in vivo and in vitro. CP reduced the antibody impairment and s timulated glomerular infiltration by mononuclear leukocytes whose medi ator spectrum was oriented to repair. IMP failed to stop the impairmen t and aggravated the infiltration. The resultant chaotic accumulation of the extracellular matrix raised the risk of sclerosis. CP showed th e advantages in experiment demonstrable also in the clinical setting.